Senior Scientist, Protein Homeostasis Cell Biology

Company: Disability Solutions
Location: San Diego
Posted on: November 3, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .The Oncogenesis Thematic Research Center at BMS is one of the fundamental research and development engines delivering oncology therapeutics to patients. With a major focus of exploiting BMS' expertise in protein degradation, we discover and develop therapies aimed at tumor intrinsic vulnerabilities and mechanisms of resistance, targeting protein classes that were previously deemed undruggable.The Protein Homeostasis (PH) Group within the Oncogenesis TRC is focused on investigating and developing novel approaches to manipulate proteostatic processes for therapeutic benefit. We are seeking a skilled and passionate cell biologist to join us in this innovative research and in the advancement of new classes of oncology therapeutics to the clinic. The successful candidate will, working with a multidisciplinary team of discovery scientists, design and execute in vitro studies that further our understanding of how proteostatic mechanisms can be co-opted to exploit vulnerabilities of difficult-to-treat cancers.Responsibilities will include the following:

• Plan, execute, and report on molecular and cellular biology studies to characterize the mechanism of action of targeted protein degraders and other induced protein proximity agents.
• Lead biology project(s) pursuing novel therapeutic targets and/or modes of targeted protein degradation.
• Participate in multidisciplinary working groups to develop and apply new methods and technologies to accelerate PH research.
• Collaborate with other oncology discovery scientists to advance early concepts to robust IND-enabling packages.
• Represent the PH biology group on project teams and at departmental meetings.
• Supervise and mentor early career scientists within the PH group.Basic Qualifications:
  • Bachelor's Degree
    • 7+ years of academic and / or industry experienceOr
      • Master's Degree
        • 5+ years of academic and / or industry experienceOr
          • Ph.D. or equivalent advanced degree in the Life Sciences
            • 2+ of academic and / or industry experiencePreferred Qualifications:
              • Deep expertise in contemporary molecular and cellular biology practices, techniques, and instrumentation.
              • Extensive experience in cell-based assay development, with a working knowledge of biochemical, biophysical, and 'omics assays.
              • Demonstrable track record of rigorous and creative research, characterizing molecular mechanisms and/or cellular signaling pathways in mammalian systems.
              • Experience in the ubiquitin-proteasome system, protein quality control pathways, and/or cancer biology are a plus.
              • Proficiency with scientific data analysis tools and biological statistics.
              • Strong written and oral communication skills.
              • Ability to work in a fast-paced and collaborative team environment, and with adaptability in accordance with research program needs.The starting compensation for this job is a range from $109,000 - $150,700 plus incentive cash and stock opportunities (based on eligibility).The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.Final, individual compensation will be decided based on demonstrated experience.Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.#LI-OnsiteIf you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Highland , Senior Scientist, Protein Homeostasis Cell Biology, Other , San Diego, California